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Response of the Rat's Hepatic Drug-Metabolizing Enzyme System to Chemotherapy of Trypanosoma B. Brucei Infections With Berenil and Suramin

Response of the Rat's Hepatic Drug-Metabolizing Enzyme System to Chemotherapy of Trypanosoma B. Brucei Infections With Berenil and Suramin

G O Emerole, M I Thabrew

Enzyme. 1984;31(3):129-36.

PMID: 6734575

Abstract:

Berenil (4,4-diamidinodiazoaminobenzene-diacetamide acetate) or Suramin [sodium salt of 8-(3-benzamido-4-methylbenzamido)-naphthalene-1,3,5-trisulfonic acid] treatment of rats infected with Trypanosoma b. brucei enhanced hepatic microsomal aniline hydroxylase and p-aminopyrine N-demethylase activities. While Suramin inhibited significantly the activities of cytoplasmic glutamate dehydrogenase and lactate dehydrogenase, Berenil had no effect. The kinetic profiles of these enzymes consistently showed a Km value similar to that of controls. Both cytosolic and microsomal glutathione-S transferase and microsomal epoxide hydratase were unaffected by Suramin. However, a significant increase in cytosolic glutathione-S transferase was observed with Berenil. Microsomal phospholipids were not affected by any of the drugs.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP129464	Suramin sodium salt		129-46-4	Price

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