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Restoration of anti-interleukin-1 Depressed Natural Killer Activity by Human Recombinant Interferon Alpha or Gamma, Human Recombinant interleukin-2 and Indomethacin

Restoration of anti-interleukin-1 Depressed Natural Killer Activity by Human Recombinant Interferon Alpha or Gamma, Human Recombinant interleukin-2 and Indomethacin

P Conti, M Reale, P U Angeletti, C A Dinarello

Int J Immunopharmacol. 1988;10(8):907-11.

PMID: 3145923

Abstract:

The lymphokines interleukin-2 and interferon alpha or gamma are synthesized and secreted by activated mononuclear cells (MC) and play a critical role in the proliferative expansion of T-lymphocyte effector cells during the immune response. The pretreatment of human peripheral blood mononuclear cells (PBMC) with antibody IgG against human interleukin-1 (IL-1) from normal rabbit serum, inhibited their natural killer (NK) activity against both myeloid (K562) and lymphoid (MOLT-4) cell lines. Percent specific lysis of tumor cells decreased by increasing the antibody anti-IL-1 dose in an almost linear fashion. When the effector cells were pretreated with human recombinant interleukin-2, human interferon alpha or gamma and indomethacin alone or in combination, the inhibitory effect of antibody against human IL-1 was almost totally reversed.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR4248606	Interleukin-2 human			Price

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