Home
Resources
Publications
Resveratrol Analogue, trans-4,4'-dihydroxystilbene (DHS), Inhibits Melanoma Tumor Growth and Suppresses Its Metastatic Colonization in Lungs

Resveratrol Analogue, trans-4,4'-dihydroxystilbene (DHS), Inhibits Melanoma Tumor Growth and Suppresses Its Metastatic Colonization in Lungs

Bhaskar Saha, Ganesh B Pai, Mahesh Subramanian, Pooja Gupta, Mrityunjay Tyagi, Birija Sankar Patro, Subrata Chattopadhyay

Biomed Pharmacother. 2018 Nov;107:1104-1114.

PMID: 30257322

Abstract:

The prevalence of melanoma and the lack of effective therapy for metastatic melanoma warrant extensive and systematic evaluations of small molecules in cellular and pre-clinical models. We investigated, herein, the antitumor and anti-metastatic effects of trans-4,4'-dihydroxystilbene (DHS), a natural product present in bark of Yucca periculosa, using in vitro and in vivo melanoma murine models. DHS showed potent melanoma cytotoxicity, as determined by MTT and clonogenic assay. Further, DHS induced cytotoxicity was mediated through apoptosis, which was assessed by annexin V-FITC/PI, sub-G1 and caspase activation assays. In addition, DHS inhibited cell proliferation by inducing robust cell cycle arrest in G1-phase. Imperatively, these inhibitory effects led to a significant reduction of melanoma tumor in pre-clinical murine model. DHS also inhibited cell migration and invasion of melanoma cells, which were examined using wound healing and Transwell migration/invasion assays. Mechanistically, DHS modulated the expressions of several key metastasis regulating proteins e.g., MMP-2/9, N-cadherin, E-cadherin and survivin. We also showed the anti-metastatic effect of DHS in a melanoma mediated lung metastasis model in vivo. DHS significantly reduced large melanoma nodule formation in the parenchyma of lungs. Therefore, DHS may represent a promising natural drug in the repertoire of treatment against melanoma tumor growth and metastasis.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP18869302	trans-4,4′-Dibromostilbene		18869-30-2	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: