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Review: Patient-controlled Transdermal 4-hydroxytamoxifen (4-OHT) vs. Oral Tamoxifen: A Systematic Review and Meta Analysis

Review: Patient-controlled Transdermal 4-hydroxytamoxifen (4-OHT) vs. Oral Tamoxifen: A Systematic Review and Meta Analysis

Usha Sundralingam, Tahir Mehmood Khan, Sumita Elendran, Saravanan Muniyandy, Uma D Palanisamy

Pak J Pharm Sci. 2019 May;32(3):1121-1128.

PMID: 31278729

Abstract:

There has been a number of studies looking into an alternative mode of therapy for the treament of breast cancer via 4-hydroxytamoxifen (4-OHT) transdermal administration.This systematic review aims to compare the safety and efficacy of a transdermal 4-OHT local therapy and oral tamoxifen (oral-T) on the treatment of ductal carcinoma in situ breast cancer. Through a systematic search of health science databases, eligible trials were located and the end points assessed were Ki-67 labeling index, concentration of 4-OHT in breast adipose tissue (ng/g) and plasma (ng/ml). Revman 5.3 version was used to perfom the meta-analysis. Three trials were identified (n=103), while only two were included for meta analysis. The mean difference between the two studies included were 0.40 and -10.58. Overall the I2 value was 89.0%, (Tau2 =53.86) and the differences between the two trials were statistically significant p=0.002. The meta analysis of the randomized controlled trials showed that the use of local transdermal therapy of 4-OHT gel is more safer than oral-T. However, due to the limited number of studies, the potential use of 4-OHT topical transdermal therapy for the treatment of breast cancer could not be concluded for healthcare professionals.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP68392358	4-Hydroxytamoxifen		68392-35-8	Price

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