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Rhamnetin Induces Apoptosis in Human Breast Cancer Cells via the miR-34a/Notch-1 Signaling Pathway

Rhamnetin Induces Apoptosis in Human Breast Cancer Cells via the miR-34a/Notch-1 Signaling Pathway

Lan Lan, Yue Wang, Zhanyu Pan, Bin Wang, Zhensong Yue, Zhansheng Jiang, Ling Li, Cong Wang, Hongmei Tang

Oncol Lett. 2019 Jan;17(1):676-682.

PMID: 30655816

Abstract:

The present study aimed to investigate whether rhamnetin induced apoptosis in human breast cancer cells and the underlying molecular mechanism of this anti cancer effect. The treatment of MCF-7 cells with rhamnetin was able to significantly inhibit cell proliferation and induce caspase-3/9 activity in a dose- and time-dependent manner, compared with untreated cells. In addition, treatment with rhamnetin was able to significantly promote the expression of p53 protein and microRNA (miR-)34a compared with untreated cells. The treatment with rhamnetin also suppressed the expression of Notch1 protein in MCF-7 cells compared with untreated cells. Subsequently, miR-24a expression was promoted in rhamnetin-treated MCF-7 cells using a miR-34a plasmid. The overexpression of miR-34a was able to significantly inhibit cell viability and induce caspase-3/9 activity in MCF-7 cells following treatment with rhamnetin. Furthermore, the overexpression of miR-34a was able to significantly promote the expression of p53 protein and miR-34a, and suppress the expression of Notch1 protein in rhamnetin-treated MCF-7 cells. Therefore, the results of the present study demonstrated that rhamnetin induced apoptosis in human breast cancer cells via the miR-34a/Notch-1 signaling pathway.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP90197	Rhamnetin		90-19-7	Price

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