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Rhapontigenin From Rheum Undulatum Protects Against Oxidative-Stress-Induced Cell Damage Through Antioxidant Activity

Rhapontigenin From Rheum Undulatum Protects Against Oxidative-Stress-Induced Cell Damage Through Antioxidant Activity

Rui Zhang, Kyoung Ah Kang, Mei Jing Piao, Kyoung Hwa Lee, Hye Suk Jang, Min Jeong Park, Bum Joon Kim, Jin Sook Kim, Young Sup Kim, Shi Yong Ryu, Jin Won Hyun

J Toxicol Environ Health A. 2007 Jul;70(13):1155-66.

PMID: 17558811

Abstract:

The antioxidant properties of rhapontigenin and rhaponticin isolated from Rheum undulatum were investigated. Rhapontigenin was found to scavenge intracellular reactive oxygen species (ROS), the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, and hydrogen peroxide (H2O2). The radical scavenging effect of rhapontigenin was more effective than rhaponticin. Rhapontigenin protected against H2O2-induced membrane lipid peroxidation and cellular DNA damage, which are the main targets of oxidative stress-induced cellular damage. The radical scavenging activity of rhapontigenin protected Chinese hamster lung fibroblast (V79-4) cells exposed to H2O2 by inhibiting apoptosis. Rhapontigenin inhibited cell damage induced by serum starvation and was also found to increase the activity of catalase and its protein expression. Further, rhapontigenin increased phosphorylation of extracellular signal-regulated kinase (ERK) and inhibited the activity of activator protein 1 (AP-1), a redox-sensitive transcription factor. In summary, these results suggest that rhapontigenin protects V79-4 cells against oxidative damage by enhancing the cellular antioxidant activity and modulating cellular signal pathways.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP500652	Rhapontigenin		500-65-2	Price

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