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Roimatacene: An Antibiotic Against Gram-negative Bacteria Isolated From Cystobacter Ferrugineus Cb G35 (Myxobacteria)

Roimatacene: An Antibiotic Against Gram-negative Bacteria Isolated From Cystobacter Ferrugineus Cb G35 (Myxobacteria)

Wiebke Zander, Klaus Gerth, Kathrin I Mohr, Wolfgang Kessler, Rolf Jansen, Rolf Müller

Chemistry. 2011 Jul 4;17(28):7875-81.

PMID: 21618624

Abstract:

Roimatacene (1) was isolated from the myxobacterium Cystobacter ferrugineus strain Cb G35 in a bioactivity-guided process, by following the antimicrobial activity against Escherichia coli. Since 1 was extremely sensitive to oxygen, a protective isolation and handling protocol was developed, by utilizing the free radical scavenger 4-ethoxyphenol. The structure of 1 was determined by HRMS, 1D and 2D NMR spectroscopy and chemical derivatization to acetonides and Mosher esters to finally establish the absolute configuration. Methionine and acetate were identified as building blocks in the biosynthesis of 1 by feeding experiments with differently (13)C-labeled precursors. The antimicrobial activity of 1 was determined in a broad screening revealing 1 to inhibit several Gram-negative bacteria.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP622628	4-Ethoxyphenol		622-62-8	Price

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