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Role of angiopoietin-2, Endoglin, and Placental Growth Factor in HIV-associated Preeclampsia

Role of angiopoietin-2, Endoglin, and Placental Growth Factor in HIV-associated Preeclampsia

Nokuzola Mbhele, Jagidesa Moodley, Thajasvarie Naicker

Hypertens Pregnancy. 2017 Aug;36(3):240-246.

PMID: 28627965

Abstract:

Objective:
The factors angiopoeitin-2 (Ang-2), endoglin (Eng), and placental growth factor (PlGF) have been implicated in the pathophysiology of preeclampsia (PE). This study assessed their serum levels in HIV-negative and HIV-positive pregnant normotensive and pre-eclamptic women.
Methods:
Participants were recruited at the antenatal clinic, serum samples were evaluated using the Bioplex Human Cancer Biomarker (panel 2).
Results:
Ang-2 and Eng levels were higher, whilst PlGF levels were lower in the PE compared with the normotensive group. Pregnancy type had no significant effect on Ang-2 and showed a significant interaction with Eng (p < 0.0001) and PlGF (p = 0.0033). HIV status had no significant effect on angiopoeitin-2 (p = 0.4), Eng (p = 0.4), and PlGF (p = 0.7) but the levels were slightly higher in the HIV-negative cohort.
Conclusions:
This study demonstrates an elevation of Ang-2 and Eng in pre-eclamptic compared with normotensive pregnant women implicating their role in its pathogenesis.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42413055	ANGIOPOEITIN-2 human			Price

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