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Role of Farnesoid X Receptor and Bile Acids in Alcoholic Liver Disease

Role of Farnesoid X Receptor and Bile Acids in Alcoholic Liver Disease

Sharon Manley, Wenxing Ding

Acta Pharm Sin B. 2015 Mar;5(2):158-67.

PMID: 26579442

Abstract:

Alcoholic liver disease (ALD) is one of the major causes of liver morbidity and mortality worldwide. Chronic alcohol consumption leads to development of liver pathogenesis encompassing steatosis, inflammation, fibrosis, cirrhosis, and in extreme cases, hepatocellular carcinoma. Moreover, ALD may also associate with cholestasis. Emerging evidence now suggests that farnesoid X receptor (FXR) and bile acids also play important roles in ALD. In this review, we discuss the effects of alcohol consumption on FXR, bile acids and gut microbiome as well as their impacts on ALD. Moreover, we summarize the findings on FXR, FoxO3a (forkhead box-containing protein class O3a) and PPARα (peroxisome proliferator-activated receptor alpha) in regulation of autophagy-related gene transcription program and liver injury in response to alcohol exposure.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP629664819	WAY-362450		629664-81-9	Price

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