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Roles and Mechanisms of the CD38/cyclic Adenosine Diphosphate ribose/Ca(2+) Signaling Pathway

Roles and Mechanisms of the CD38/cyclic Adenosine Diphosphate ribose/Ca(2+) Signaling Pathway

Wenjie Wei, Richard Graeff, Jianbo Yue

World J Biol Chem. 2014 Feb 26;5(1):58-67.

PMID: 24600514

Abstract:

Mobilization of intracellular Ca(2+) stores is involved in many diverse cell functions, including: cell proliferation; differentiation; fertilization; muscle contraction; secretion of neurotransmitters, hormones and enzymes; and lymphocyte activation and proliferation. Cyclic adenosine diphosphate ribose (cADPR) is an endogenous Ca(2+) mobilizing nucleotide present in many cell types and species, from plants to animals. cADPR is formed by ADP-ribosyl cyclases from nicotinamide adenine dinucleotide. The main ADP-ribosyl cyclase in mammals is CD38, a multi-functional enzyme and a type II membrane protein. It has been shown that many extracellular stimuli can induce cADPR production that leads to calcium release or influx, establishing cADPR as a second messenger. cADPR has been linked to a wide variety of cellular processes, but the molecular mechanisms regarding cADPR signaling remain elusive. The aim of this review is to summarize the CD38/cADPR/Ca(2+) signaling pathway, focusing on the recent advances involving the mechanism and physiological functions of cADPR-mediated Ca(2+) mobilization.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP119340533	Cyclic adenosine diphosphate-ribose		119340-53-3	Price

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