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(RS)-alpha-methyl-4-carboxyphenylglycine (MCPG) Does Not Block Theta Burst-Induced Long-Term Potentiation in Area CA1 of Rat Hippocampal Slices

(RS)-alpha-methyl-4-carboxyphenylglycine (MCPG) Does Not Block Theta Burst-Induced Long-Term Potentiation in Area CA1 of Rat Hippocampal Slices

R E Brown, H Rabe, K G Reymann

Neurosci Lett. 1994 Mar 28;170(1):17-21.

PMID: 8041499

Abstract:

We have used the selective metabotropic glutamate receptor antagonist (RS)-alpha-methyl-4-carboxyphenylglycine (MCPG) to investigate in the CA1 hippocampal subregion in vitro whether coactivation of N-methyl-D-aspartate (NMDA) and metabotropic glutamate receptors is necessary for the induction of long-term potentiation (LTP) when LTP is induced by theta burst stimulation (TBS). When MCPG (500 microM) was bath applied 14-30 min prior to a triple high-frequency tetanization (100 Hz, 1 s) and washed out immediately afterwards the potentiation of the extracellularly recorded field potentials decayed gradually to baseline (P < 0.05) over 2-3 h. However, when MCPG was applied in the same manner before a triple TBS (10 bursts at 5 Hz, 100 Hz within the bursts) the resulting potentiation remained stable for at least 4 h. MCPG had no effect on baseline synaptic transmission or post-tetanic potentiation. These results demonstrate a clear difference in the mechanisms underlying these two different forms of LTP.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP150145894	(+)-α-Methyl-4-carboxyphenylglycine		150145-89-4	Price

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