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[Ru(dcbpy) 2 dppz] 2+ /Fullerene Cosensitized PTB7-Th for Ultrasensitive Photoelectrochemical MicroRNA Assay

[Ru(dcbpy) 2 dppz] 2+ /Fullerene Cosensitized PTB7-Th for Ultrasensitive Photoelectrochemical MicroRNA Assay

Ling-Ying Xia, Ying-Ning Zheng, Wen-Bin Liang, Meng-Jie Li, Tao Hu, Ruo Yuan, Ya-Qin Chai

Chemistry. 2019 Mar 15;25(16):4087-4092.

PMID: 30675925

Abstract:

A new cosensitization photoelectrochemical (PEC) strategy was established by using a donor-acceptor-type photoactive material, poly{4,8-bis[5-(2-ethylhexyl)thiophen-2-yl]benzo[1,2-b:4,5-b']dithiophene-2,6-diyl-alt-3-fluoro-2-[(2-ethylhexyl)carbonyl]thieno[3,4-b]thiophene-4,6-diyl} (PTB7-Th), as a signal indicator, which was cosensitized with bis(4,4'dicarboxyl-2,2'-bipyridyl)(4,5,9,14-tetraazabenzo[b]triphenylene)ruthenium(II) ([Ru(dcbpy)2 dppz]2+ ) embedded in the grooves of the DNA duplex and fullerene (nano-C60 ) immobilized on the surface of DNA nanoflowers for microRNA assay. [Ru(dcbpy)2 dppz]2+ and nano-C60 could effectively enhance the photoelectric conversion efficiency (PCE) of PTB7-Th as a result of well-matched energy levels among nano-C60 , [Ru(dcbpy)2 dppz]2+ and PTB7-Th, leading to a clearly enhanced photocurrent signal. Meanwhile, a target recycling magnification technique based on duplex-specific nuclease was applied in this work to obtain higher detection sensitivity. The proposed biosensor demonstrated excellent analytical properties within a linear detection range of 2.5 fm to 2.5 nm and a limit of detection down to 0.83 fm. Impressively, this cosensitization PEC strategy offers an effective and convenient avenue to significantly improve the PCE of a photoactive material, resulting in a remarkably improved photocurrent signal for ultrasensitive and highly accurate detection of various targets.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1850369753	DCBPy		1850369-75-3	Price
AP1867199594	mDCBPy		1867199-59-4	Price

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