Home
Resources
Publications
( S)-6-[(4-Chlorophenyl)(1 H-1,2,4-triazol-1-yl)methyl]-1-[ 11 C]methyl-1 H-benzotriazole

( S)-6-[(4-Chlorophenyl)(1 H-1,2,4-triazol-1-yl)methyl]-1-[ 11 C]methyl-1 H-benzotriazole

Kam Leung

PMID: 20641399

Abstract:

Aromatase is an enzyme complex of the cytochrome P450 superfamily (1). It is composed of P450 and a flavoprotein called NADPH-P450 reductase. Its main function is to aromatize androgens to estrogens. Aromatase is present in many tissues, including granulosa cells of the ovary, brain, fat, placenta, blood vessels, skin, bone, and endometrium. Aromatase is overexpressed in tissue of endometriosis, uterine fibroids, breast cancer, and endometrial cancer (2-6). (S)-6-[(4-Chlorophenyl)(1H-1,2,4-triazol-1-yl)methyl]-1-methyl-1H-benzotriazole (vorozole) is an aromatase inhibitor with a inhibition constant (Ki) value of 1 nM. Lidstrom et al. (7) prepared [11C]vorozole by N-methylation of (S)-6-[(4-chlorophenyl)(1H-1,2,4-triazol-1-yl)methyl]-1H-benzotriazole (nor-vorozole) to use as a positron emission tomography (PET) radioligand to study aromatase activity.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP72459586	Triazoxid		72459-58-6	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: