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S-nitrosoglutathione

S-nitrosoglutathione

Katarzyna A Broniowska, Anne R Diers, Neil Hogg

Biochim Biophys Acta. 2013 May;1830(5):3173-81.

PMID: 23416062

Abstract:

Background:
S-Nitrosoglutathione (GSNO) is the S-nitrosated derivative of glutathione and is thought to be a critical mediator of the down stream signaling effects of nitric oxide (NO). GSNO has also been implicated as a contributor to various disease states.
Scope of review:
This review focuses on the chemical nature of GSNO, its biological activities, the evidence that it is an endogenous mediator of NO action, and implications for therapeutic use.
Major conclusions:
GSNO clearly exerts its cellular actions through both NO- and S-nitrosation-dependent mechanisms; however, the chemical and biological aspects of this compound should be placed in the context of S-nitrosation as a whole.
General significance:
GSNO is a central intermediate in formation and degradation of cellular S-nitrosothiols with potential therapeutic applications; thus, it remains an important molecule of study. This article is part of a Special Issue entitled Cellular functions of glutathione.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP57564917	S-Nitrosoglutathione		57564-91-7	Price

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