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Safety Assessment of 1,2-glycols as Used in Cosmetics

Safety Assessment of 1,2-glycols as Used in Cosmetics

Wilbur Johnson Jr, Wilma F Bergfeld, Donald V Belsito, Ronald A Hill, Curtis D Klaassen, Daniel Liebler, James G Marks Jr, Ronald C Shank, Thomas J Slaga, Paul W Snyder, F Alan Andersen

Int J Toxicol. Sep-Oct 2012;31(5 Suppl):147S-68S.

PMID: 23064773

Abstract:

Caprylyl glycol and related 1,2-glycols are used mostly as skin and hair conditioning agents and viscosity agents in cosmetic products, and caprylyl glycol and pentylene glycol also function as cosmetic preservatives. The Cosmetic Ingredient Review (CIR) Expert Panel noted that, while these ingredients are dermally absorbed, modeling data predicted decreased skin penetration of longer chain 1,2-glycols. Because the negative oral toxicity data on shorter chain 1,2-glycols and genotoxicity data support the safety of the 1,2-glycols reviewed in this safety assessment, the Panel concluded that these ingredients are safe in the present practices of use and concentration described in this safety assessment.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP627861	1,2-Dioctanoylethylene glycol		627-86-1	Price

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