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Salinipyrone and Pacificanone Are Biosynthetic By-products of the Rosamicin Polyketide Synthase

Salinipyrone and Pacificanone Are Biosynthetic By-products of the Rosamicin Polyketide Synthase

Takayoshi Awakawa, Max Crüsemann, Jason Munguia, Nadine Ziemert, Victor Nizet, William Fenical, Bradley S Moore

Chembiochem. 2015 Jul 6;16(10):1443-7.

PMID: 25930739

Abstract:

Salinipyrones and pacificanones are structurally related polyketides from Salinispora pacifica CNS-237 that are proposed to arise from the same modular polyketide synthase (PKS) assembly line. Genome sequencing revealed a large macrolide PKS gene cluster that codes for the biosynthesis of rosamicin A and a series of new macrolide antibiotics. Mutagenesis experiments unexpectedly correlated salinipyrone and pacificanone biosynthesis to the rosamicin octamodule Spr PKS. Remarkably, this bifurcated polyketide pathway illuminates a series of enzymatic domain- and module-skipping reactions that give rise to natural polyketide product diversity. Our findings enlarge the growing knowledge of polyketide biochemistry and illuminate potential challenges in PKS bioengineering.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP35834265	Rosamicin		35834-26-5	Price

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