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Salvianolic Acid B Ameliorates Hyperglycemia and Dyslipidemia in db/db Mice Through the AMPK Pathway

Salvianolic Acid B Ameliorates Hyperglycemia and Dyslipidemia in db/db Mice Through the AMPK Pathway

Ming-Qing Huang, Cai-Jie Zhou, Yi-Ping Zhang, Xiao-Qin Zhang, Wen Xu, Jing Lin, Pei-Jian Wang

Cell Physiol Biochem. 2016;40(5):933-943.

PMID: 27941340

Abstract:

Background/aims:
Salvianolic acid B (Sal B), a major polyphenolic compound of Salvia miltiorrhiza Bunge, has been shown to possess potential antidiabetic activities. However, the action mechanism of SalB in type 2 diabetes has not been investigated extensively. The present study was designed to investigate the effects of Sal B on diabetes-related metabolic changes in a spontaneous model of type 2 diabetes, as well as its potential molecular mechanism.
Methods:
Male C57BL/KsJ-db/db mice were orally treated with Sal B (50 and 100 mg/kg) or metformin (positive drug, 300 mg/kg) for 6 weeks.
Results:
Both doses of Sal B significantly decreased fasting blood glucose, serum insulin, triglyceride and free fatty acid levels, reduced hepatic gluconeogenic gene expression and improved insulin intolerance in db/db mice. High dose Sal B also significantly improved glucose intolerance, increased hepatic glycolytic gene expression and muscle glycogen content, and ameliorated histopathological alterations of pancreas, similar to metformin. Sal B treatment resulted in increased phosphorylated AMP-activated protein kinase (p-AMPK) protein expression in skeletal muscle and liver, increased glucose transporter 4 (GLUT4) and glycogen synthase protein expressions in skeletal muscle, and increased peroxisome proliferator-activated receptor alpha (PPARα) and phosphorylated acetyl CoA carboxylase (p-ACC) protein expressions in liver.
Conclusion:
Our data suggest that Sal B displays beneficial effects in the prevention and treatment of type 2 diabetes at least in part via modulation of the AMPK pathway.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1674620	Metformin Related Compound B		1674-62-0	Price

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