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Santin Inhibits Influenza A Virus Replication Through Regulating MAPKs and NF-κB Pathways

Ming Zhong, Hui-Qiang Wang, Hai-Yan Yan, Shuo Wu, Zheng-Yi Gu, Yu-Huan Li

J Asian Nat Prod Res. 2019 Dec;21(12):1205-1214.

PMID: 30417663

Abstract:

Influenza A virus (IAV) causes high morbidity and significant mortality worldwide. Given the limitations of existing vaccination and antiviral drugs, it is urgent to develop new anti-influenza drugs. Flavonoids are natural polyphenolic compounds with broad applications to treatments for influenza infection. In this study, we demonstrated that santin, a flavonoid compound, showed anti-influenza activity in MDCK and THP-1 cells. Mechanistic studies revealed that santin depressed the phosphorylation of p38 MAPK, JNK/SAPK, ERK, and NF-κB factor and subsequently attenuated the expression of inflammatory cytokines in IAV-infected cells. Thus, santin is a potential candidate for the future development of anti-IAV drugs.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP27782634 Santin Santin 27782-63-4 Price
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