Home
Resources
Publications
Sedative and Anesthetic Activities of the Essential Oils of Hyptis Mutabilis (Rich.) Briq. And Their Isolated Components in Silver Catfish (Rhamdia Quelen)

Sedative and Anesthetic Activities of the Essential Oils of Hyptis Mutabilis (Rich.) Briq. And Their Isolated Components in Silver Catfish (Rhamdia Quelen)

L L Silva, Q I Garlet, S C Benovit, G Dolci, C A Mallmann, M E Bürger, B Baldisserotto, S J Longhi, B M Heinzmann

Braz J Med Biol Res. 2013 Sep;46(9):771-9.

PMID: 24068193

Abstract:

This study evaluated the sedative and anesthetic effects of the essential oils (EO) of Hyptis mutabilis (Rich.) Briq. and their isolated components on silver catfish (Rhamdia quelen). Quantitative chemical differences between the EOs obtained from leaves and inflorescences were verified, and a new chemotype rich in globulol was described. Although there were no significant differences in the time of induction for sedation and anesthesia between the EOs, only the leaf EO at 344 mg/L anesthetized all fish without side effects. Fractionation of the leaf EO was carried out by column chromatography. The isolated compounds [(+)-1-terpinen-4-ol and (-)-globulol] showed different activity from that detected for the leaf EO in proportional concentrations and similar sedation to a eugenol control at 10 mg/L. However, fish exposed to 1-terpinen-4-ol (3 and 10 mg/L) did not remain sedated for 30 min. Anesthesia was obtained with 83-190 mg/L globulol, but animals showed loss of mucus during induction and mortality at these concentrations. Synergism of the depressor effects was detected with the association of globulol and benzodiazepine (BDZ), compared with either drug alone. Fish exposed to BDZ or globulol+BDZ association showed faster recovery from anesthesia in water containing flumazenil, but the same did not occur with globulol. In conclusion, the use of globulol in aquaculture procedures should be considered only at sedative concentrations of 10 and 20 mg/L, and its mechanism of action seems not to involve the GABAA-BDZ system.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP489418	(−)-Globulol		489-41-8	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: