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Selective Adsorption of Oppositely Charged PNIPAAM on Halloysite Surfaces: A Route to Thermo-Responsive Nanocarriers

Selective Adsorption of Oppositely Charged PNIPAAM on Halloysite Surfaces: A Route to Thermo-Responsive Nanocarriers

Giuseppe Cavallaro, Giuseppe Lazzara, Lorenzo Lisuzzo, Stefana Milioto, Filippo Parisi

Nanotechnology. 2018 Aug 10;29(32):325702.

PMID: 29771681

Abstract:

Halloysite nanotubes were functionalized with stimuli-responsive macromolecules to generate smart nanohybrids. Poly(N-isopropylacrylamide)-co-methacrylic acid (PNIPAAM-co-MA) was selectively adsorbed into halloysite lumen by exploiting electrostatic interactions. Amine-terminated PNIPAAM polymer was also investigated that selectively interacts with the outer surface of the nanotubes. The adsorption site has a profound effect on the thermodynamic behavior and therefore temperature responsive features of the hybrid material. The drug release kinetics was investigated by using diclofenac as a non-steroidal anti-inflammatory drug model. The release kinetics depends on the nanoarchitecture of the PNIPAAM/halloysite based material. In particular, diclofenac release was slowed down above the LCST for PNIPAAM-co-MA/halloysite. Opposite trends occurred for halloysite functionalized with PNIPAAM at the outer surface. This work represents a further step toward the opportunity to extend and control the delivery conditions of active species, which represent a key point in technological applications.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
LS74682	Poly(N-isopropyl acrylamide), amine terminated			Price

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