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Selective Monolithiation of Dibromobiaryls Using Microflow Systems

Selective Monolithiation of Dibromobiaryls Using Microflow Systems

Aiichiro Nagaki, Naofumi Takabayashi, Yutaka Tomida, Jun-ichi Yoshida

Org Lett. 2008 Sep 18;10(18):3937-40.

PMID: 18720991

Abstract:

Selective monolithiation of dibromobiaryls, such as 2,2'-dibromobiphenyl, 4,4'-dibromobiphenyl, 2,7-dibromo-9,9-dioctylfluorene, 2,2'-dibromo-1,1'-binaphthyl, and 5,5'-dibromo-2,2'-bithiophene, with 1 equiv of n-butyllithium followed by the reaction with electrophiles was achieved using a microflow system by virtue of fast micromixing and precise temperature control. Sequential introduction of two different electrophiles based on this method was also achieved using a microflow system composed of four micromixers and four microtube reactors.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP4805225	5,5′-Dibromo-2,2′-bithiophene		4805-22-5	Price

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