Home
Resources
Publications
Selective Sensitization to Penicillin V With Tolerance to Other Betalactams

Selective Sensitization to Penicillin V With Tolerance to Other Betalactams

Leticia Sánchez-Morillas, Patricia Rojas-Pérez-Ezquerra, Rosario González-Mendiola, Prado Gómez-Tembleque, Julio Laguna-Martínez

Recent Pat Inflamm Allergy Drug Discov. 2014 Jan;8(1):74-6.

PMID: 24447049

Abstract:

Background:
Penicillin G and V have the same betalactam ring. Penicillin V (phenoxymethylpenicillin) results from the substitution of the phenyl acetic acid of benzylpenicillin by the phenoxy methyl side chain.
Methods:
Our patient was a 34-year-old man who experienced generalized urticaria after ingestion of Penicillin V. We performed skin prick tests and intradermal tests with a battery of betalactams including Penicillin V. We also determined specific IgE against penicillin V, penicillin G, amoxicillin, and ampicillin and performed a single-blind oral challenge with Penicillin V, amoxicillin, cefuroxime, and ceftazidime.
Results:
The results of skin prick and intradermal tests with the betalactams included were negative. Specific IgE with betalactams was < 0.10 IU/L. The result of a single-blind oral challenge with Penicillin V was positive: 40 minutes after receiving 125 mg of Penicillin V, the patient presented generalized pruritus with hives on his back and chest. He tolerated oral administration of amoxicillin, cefuroxime, and ceftazidime.
Conclusion:
We report an exceptional case of sensitization to Penicillin V with negative results in the allergy workup. Diagnosis was based on a positive single-blind oral challenge result. The patient tolerated other betalactams. We provide a brief summary of the most relevant recent patents.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP87081	Penicillin V		87-08-1	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: