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Selenomethionine and Methioninase: Selenium Free Radical Anticancer Activity

Selenomethionine and Methioninase: Selenium Free Radical Anticancer Activity

Julian E Spallholz

Methods Mol Biol. 2019;1866:199-210.

PMID: 30725417

Abstract:

Colloidal selenium, was first used to treat cancer as early as 1911 in both humans and mice. Selenium was identified as the toxic component in forage plants of sheep, cattle, and horses in the 1930s. The animal toxicity of selenium compounds was determined to be from the metabolism by animals of the elevated concentrations of Se-methylselenocysteine and selenomethionine in plants. The metabolism of both Se-methylselenocysteine and selenomethionine by animals gives rise to the metabolite, methylselenide (CH3Se-), which if in sufficient concentration oxidizes thiols and generates superoxide and other reactive oxygen species. Cancer cells that may overly express methionine gamma-lyase, or beta-lyase (methioninase), by induced viral genomic expression, are susceptible to free radical-induced apoptosis from selenomethionine or Se-methylselenocysteine supplementation.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP3211765-A	Selenomethionine		3211-76-5	Price

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