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Self-assembled Microspheres Driven by Dipole-Dipole Interactions: UCST-type Transition in Water

Self-assembled Microspheres Driven by Dipole-Dipole Interactions: UCST-type Transition in Water

Nobuyuki Morimoto, Kanna Muramatsu, Tetsuichi Wazawa, Yuichi Inoue, Makoto Suzuki

Macromol Rapid Commun. 2014 Jan;35(1):103-8.

PMID: 24307305

Abstract:

A double hydrophilic block copolymer, poly(ethylene glycol)-poly(3-dimethyl (methacryloyloxyethyl) ammonium propane sulfonate) (PEG-SB), is synthesized by reversible addition-fragmentation transfer (RAFT) polymerization using PEG methyl ether (4-cyano-4-pentanoate dodecyl trithiocarbonate) as a chain transfer agent. PEG-SB forms multi-layered microspheres with dipole-dipole interactions of the SB side chains as the driving force. The PEG-SB polymers show an upper critical solution temperature (UCST) and the UCST is controllable by the polymerization degree. The PEG-SB microspheres are dissociated above the UCST and then monodispersed microspheres (∼1 μm) are obtained when the solution temperature is decreased below the UCST again. The disassociation/association of the microspheres is also controllable using the concentration of NaCl. These multi-responsive microspheres could be a powerful tool in the field of nano-biotechnology.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
LS7411229	Poly(ethylene glycol) methyl ether (4-cyano-4-pentanoate dodecyl trithiocarbonate)			Price

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