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Self-Assembly and Antitumor Activity of a Polyoxovanadate-Based Coordination Nanocage

Self-Assembly and Antitumor Activity of a Polyoxovanadate-Based Coordination Nanocage

Yan Zheng, Hongmei Gan, Yao Zhao, Wanling Li, Yuchen Wu, Xuechun Yan, Yifan Wang, Jinhua Li, Juan Li, Xinlong Wang

Chemistry. 2019 Dec 2;25(67):15326-15332.

PMID: 31568591

Abstract:

A new supramolecular nanocage, VMOP-31, based on polyoxovanadate as the molecular building block, has been designed and synthesized under solvothermal conditions. The structure of VMOP-31 was determined by single-crystal and powder X-ray diffraction, FTIR spectroscopy, UV/Vis spectrophotometry, and thermogravimetric analysis. The nanocage exhibits octahedral geometry and is constructed of six {V5 O9 Cl(COO)4 } at the vertices and eight TATB (H3 TATB=4,4',4''-(s-triazine-2,4,6-triyl)tribenzoic acid) ligands on the faces. Impressively, VMOP-31 exhibited high efficiency in the inhibition of cell growth of solid tumors, such as human liver cancer cells SMMC-7721, and superior results in the treatment of liver tumors in mice compared with classic cisplatin. Detailed studies revealed that the potential mechanism of cell death induced by VMOP-31 involves cell cycle arrests, DNA damage, and subsequent apoptosis. Moreover, VMOP-31 exhibited negligible side effects in the mice compared with cisplatin. To the best of our knowledge, VMOP-31 is the first supramolecular nanocage applied to hepatic tumors both in vitro and in vivo.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP61414162	4,4′,4″-s-Triazine-2,4,6-triyl-tribenzoic acid		61414-16-2	Price

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