Home
Resources
Publications
Self-Assembly of Hybrid Lipid Membranes Doped With Hydrophobic Organic Molecules at the Water/Air Interface

Self-Assembly of Hybrid Lipid Membranes Doped With Hydrophobic Organic Molecules at the Water/Air Interface

Xingyao Feng, Teng Ma, Daisuke Tadaki, Ayumi Hirano-Iwata

J Vis Exp. 2020 May 1;(159).

PMID: 32421002

Abstract:

Because of their unique properties, including an ultrathin thickness (3-4 nm), ultrahigh resistivity, fluidity and self-assembly ability, lipid bilayers can be readily functionalized and have been used in various applications such as bio-sensors and bio-devices. In this study, we introduced a planar organic molecule: copper (II) 2,9,16,23-tetra-tert-butyl-29H,31H-phthalocyanine (CuPc) to dope lipid membranes. The CuPc/lipid hybrid membrane forms at the water/air interface by self-assembly. In this membrane, the hydrophobic CuPc molecules are located between the hydrophobic tails of lipid molecules, forming a lipid/CuPc/lipid sandwich structure. Interestingly, an air-stable hybrid lipid bilayer can be readily formed by transferring the hybrid membrane onto a Si substrate. We report a straightforward method for incorporating nanomaterials into a lipid bilayer system, which represents a new methodology for the fabrication of biosensors and biodevices.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP15275522	Copper(II) 4,4′,4′′,4′′′-tetraaza-29H,31H-phthalocyanine		15275-52-2	Price
AP35984931	2,9,16,23-Tetra-tert-butyl-29H,31H-phthalocyanine		35984-93-1	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: