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Self-healing pH-sensitive Poly[(methyl Vinyl Ether)-Alt-(Maleic Acid)]-Based Supramolecular Hydrogels Formed by Inclusion Complexation Between Cyclodextrin and Adamantane

Xiaoe Ma, Naizhen Zhou, Tianzhu Zhang, Wanjun Hu, Ning Gu

Mater Sci Eng C Mater Biol Appl. 2017 Apr 1;73:357-365.

PMID: 28183619

Abstract:

Self-healing materials are of interest for drug delivery, cell and gene therapy, tissue engineering, and other biomedical applications. In this work, on the base of biocompatible polymer poly(methyl vinyl ether-alt-maleic acid) (P(MVE-alt-MA)), host polymer β-cyclodextrin-grafted P(MVE-alt-MA) (P(MVE-alt-MA)-g-β-CD) and guest polymer adamantane-grafted P(MVE-alt-MA) (P(MVE-alt-MA)-g-Ad) were first prepared. Then through taking advantage of the traditional host-guest interaction of β-cyclodextrin and adamantane, a novel self-healing pH-sensitive physical P(MVE-alt-MA)-g-β-CD/P(MVE-alt-MA)-g-Ad supramolecular hydrogels were obtained after simply mixing the aqueous solution of host polymer and guest polymer. This kind of supramolecular hydrogels not only possess pH-sensitivity, but also possess the ability to repair themselves after being damaged.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP25153406 Poly(methyl vinyl ether-alt-maleic acid) Poly(methyl vinyl ether-alt-maleic acid) 25153-40-6 Price
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