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Sensitive Spectrophotometric Method for Quantitation of Guaifenesin and Dropropizine in Their Dosage Forms

Ola M Abdallah

Int J Anal Chem. 2010;2010:704564.

PMID: 20671996

Abstract:

Guaifenesin and dropropizine were analyzed through oxidation with periodic acid to give formaldehyde which was allowed to condense with 4-Amino-5-hydrazino-4H [1,2,4]-triazole-3-thiol (AHTT). The condensation product was further oxidized to yield a purple colored compound with maximum absorption at 550 nm. Beer's law was obeyed in the range of 5-45 mug mL(-1) for guaifenesin and 10-80 mug mL(-1) for dropropizine. Both drugs were also successfully determined in their dosage forms.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP17692318 (±)-Dropropizine (±)-Dropropizine 17692-31-8 Price
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