Home
Resources
Publications
Sensitization to Insulin Induced by Beta,beta'-Methyl-Substituted Hexadecanedioic Acid (MEDICA 16) in Obese Zucker Rats in Vivo

Sensitization to Insulin Induced by Beta,beta'-Methyl-Substituted Hexadecanedioic Acid (MEDICA 16) in Obese Zucker Rats in Vivo

N Mayorek, B Kalderon, E Itach, J Bar-Tana

Diabetes. 1997 Dec;46(12):1958-64.

PMID: 9392480

Abstract:

Beta,beta'-methyl-substituted hexadecanedioic acid (MEDICA 16) consists of a nonmetabolizable long-chain fatty acid designed to probe the effect exerted by fatty acids on insulin sensitivity. The effect of MEDICA 16 was evaluated in insulin-resistant Zucker (fa/fa) rats in terms of liver, muscle, and adipose tissue response to clamped euglycemic hyperinsulinemia in vivo. Nontreated Zucker rats were insulin resistant, maintaining basal rates of total-body glucose disposal, glucose production in liver, free fatty acid (FFA) flux into plasma, and FFA reesterification in adipose tissue, irrespective of the insulin levels induced. MEDICA 16 treatment resulted in an insulin-induced decrease in hepatic glucose production, together with an insulin-induced increase in total-body glucose disposal. Intracellular reesterification of lipolysed FFA in adipose tissue was specifically activated by MEDICA 16, resulting in a pronounced decrease in FFA release, with a concomitant decrease in plasma FFA. In conclusion, MEDICA 16 treatment results in the sensitization of liver, muscle, and adipose tissue to insulin in an animal model for obesity-induced insulin resistance.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
ALP87272206	MEDICA 16		87272-20-6 (anhydrous)	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: