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Separation of Octopamine Racemate on (R,S)-2-amino-1-phenylethanol Imprinted polymer--Experimental and Computational Studies

Separation of Octopamine Racemate on (R,S)-2-amino-1-phenylethanol Imprinted polymer--Experimental and Computational Studies

Monika Sobiech, Teresa Żołek, Piotr Luliński, Dorota Maciejewska

Talanta. 2016;146:556-67.

PMID: 26695304

Abstract:

Ten molecularly imprinted polymers coded as MIP1-MIP10 were prepared by the radical bulk polymerization using (R,S)-(±)-2-amino-1-phenylethanol as the structural analog of the target analyte (R,S)-octopamine. The functional monomers, 4-vinylbenzoic acid (1), methacrylic acid (2), acrylic acid (3), trifluoromethacrylic acid (4), itaconic acid (5), acrylamide (6), isopropenylbenzene (7), 2-hydroxyethyl methacrylate (8), 2-(diethylamino)ethyl methacrylate (9), allylamine (10) were polymerized consecutively with the ethylene glycol dimethacrylate cross-linker in methanol as the porogen. On the basis of the binding capacity of (R,S)-octopamine MIP1 with affinity factor equal to 6.37 was selected for further analysis. The affinity of polymer matrix MIP1 was tested by the non-competitive binding experiments of eight structurally related analytes. Finally, molecularly imprinted solid phase extraction (MISPE) of (R,S)-octopamine from spiked human serum albumin was carried out in order to verify the applicability of novel sorbent. The molecular modeling was employed to rationalize the stereodifferentiation of the analytes by the stereospecific sites formed in the polymer matrix.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1517697	(R)-(+)-1-Phenylethanol		1517-69-7	Price

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