Home
Resources
Publications
Serum Creatinine: Not So Simple!

Serum Creatinine: Not So Simple!

Pierre Delanaye, Etienne Cavalier, Hans Pottel

Nephron. 2017;136(4):302-308.

PMID: 28441651

Abstract:

Measuring serum creatinine is cheap and commonly done in daily practice. However, interpretation of serum creatinine results is not always easy. In this review, we will briefly remind the physiological limitations of serum creatinine due notably to its tubular secretion and the influence of muscular mass or protein intake on its concentration. We mainly focus on the analytical limitations of serum creatinine, insisting on important concept such as reference intervals, standardization (and IDMS traceability), analytical interferences, analytical coefficient of variation (CV), biological CV and critical difference. Because the relationship between serum creatinine and glomerular filtration rate is hyperbolic, all these CVs will impact not only the precision of serum creatinine but still more the precision of different creatinine-based equations, especially in low or normal-low creatinine levels (or high or normal-high glomerular filtration rate range).

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AS2121435	Human serum (low creatinine)			Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: