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Serum Levels and Urine Detection of Centruroides Sculpturatus Venom in Significantly Envenomated Patients

Serum Levels and Urine Detection of Centruroides Sculpturatus Venom in Significantly Envenomated Patients

Peter Chase, Leslie Boyer-Hassen, Jude McNally, H L Vazquez, Andreas A Theodorou, Frank Gardner Walter, Alejandro Alagon

Clin Toxicol (Phila). 2009 Jan;47(1):24-8.

PMID: 18763156

Abstract:

Introduction:
Envenomation by Centruroides sculpturatus can cause systemic signs and symptoms requiring treatment. The toxicokinetics of C. sculpturatus venom has not been described.
Methods:
Venom components were separated for cross-reactivity testing. Serum and urine collected from three patients envenomated by C. sculpturatus had venom levels determined by sandwich enzyme-linked immunosorbent assay (ELISA).
Results:
Western blot analysis indicated recognition of C. sculpturatus venom by Alacramyn, an equine F(ab')(2) antivenom developed against Centruroides scorpion venoms, including C. sculpturatus. Serum venom levels in ng/mL with post-envenomation times in minutes (min) were as follows: 85-year-old woman = 8.2 (approximately 150), 2.8 (515), 1.6 (1,200); 14-month-old girl = 29.7 (approximately 50), 5.0 (729); 3-year-old girl = 11.1 (approximately 313), urine venom level of 9.0 (approximately 490).
Conclusion:
There is sufficient venom cross-antigenicity among different Centruroides species to allow this ELISA technique with Alacramyn to determine serum and urine C. sculpturatus venom concentrations in envenomated patients.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR4245250	Scorpion venom from Centruroides sculpturatus			Price

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