Home
Resources
Publications
Sesquiterpene Lactone, a Potent Drug Molecule From Artemisia Pallens Wall With Anti-Inflammatory Activity

Sesquiterpene Lactone, a Potent Drug Molecule From Artemisia Pallens Wall With Anti-Inflammatory Activity

Anjali D Ruikar, Ashwini V Misar, Ravindra B Jadhav, Supada R Rojatkar, Arvind M Mujumdar, Vedavati G Puranik, Nirmala R Deshpande

Arzneimittelforschung. 2011;61(9):510-4.

PMID: 22029227

Abstract:

The present study was carried out to investigate the anti-inflammatory activities of bioactive secondary metabolites of Artemisia pallens Wall, an aromatic herb from family Asteraceae. The results provide evidence for the topical anti-inflammatory properties of Artemisia pallens Wall. The compounds were isolated from the acetone extract of the plant material. The isolates were tested on Swiss albino mice using 12-O-tetradecanoyl phorbol-13-acetate (TPA) induced ear edema. One of the molecules from the extract indicated potent anti-inflammatory activity equivalent to indometacin (CAS 53-86-1). Elucidation of the molecular structures by single crystal x-ray diffraction studies revealed the conformational differences that the six membered rings in both the molecules are at an angle of 28.79 degrees. Presence of hydroxy function for compound 2 may be responsible for higher potency.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP53861-A	Indomethacin - CAS 53-86-1		53-86-1	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: