Home
Resources
Publications
Sesquiterpenes and Diterpenes With Cytotoxic Activities From the Aerial Parts of Carpesium Humile

Sesquiterpenes and Diterpenes With Cytotoxic Activities From the Aerial Parts of Carpesium Humile

Dong-Dong Xu, Yuan Yan, Chun-Xiao Jiang, Jing-Jing Liang, Hong-Fang Li, Quan-Xiang Wu, Ying Zhu

Fitoterapia. 2018 Jul;128:50-56.

PMID: 29689329

Abstract:

Carpesium humile Winkl is an endemic Chinese species and no previous phytochemical studies have been reported for this species. Two new germacranolides (1 and 2) and a new phytane diterpene (5), together with five known compounds (two sesquiterpenoids and three diterpenoids), were isolated from the aerial parts of C. humile. Their structures were elucidated on the basis of extensive spectroscopic analysis. The conformations and absolute configurations of 1 and 2 were established by combinative analysis of NMR, CD exciton chirality, and X-ray crystallography data. Four germacranolides (1-4) showed strong cytotoxic activities, with broad spectrum activities against six human cancer (HepG2, HeLa, HL60, SGC7901, Lewis, and MDA231) cell lines in vitro using MTT assay, with IC50 values from 3.09 to 7.71 μg/mL. Diterpenes (5, 6, and 8) also displayed good cytotoxic activities for selected cancer cell lines, with IC50 values in the range 5.46-8.08 μg/mL.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP638368	Phytane		638-36-8	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: