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[Sex Differentiation and Sex Chromosomes]

Toshikatsu Shinka, Yutaka Nakahori

Nihon Rinsho. 2004 Feb;62(2):247-54.

PMID: 14968529

Abstract:

The mechanisms for sex differentiation and the genes on the sex chromosomes are varied among different species. For human, SRY is the only testis-determining factor on the Y chromosome and triggers the cascade for male sex-determination. However, even if normal SRY exists, the haploinsufficienty of SOX9 or KTS+ splicing form of WT-1 can cause male-to-female sex reversal. Furthermore, the duplication of the partial region on the X chromosome including DAX-1 gene can also cause male-to-female sex reversal. The sex-determining system seems to be sensitive for the gene dosage or the gene expression level.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
IAR42414962 WT-1 (+KTS) human WT-1 (+KTS) human Price
IAR42414963 WT-1 (-KTS) human WT-1 (-KTS) human Price
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