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Sex-related Differences in the Plasma Protein Binding of Lignocaine and Diazepam

Sex-related Differences in the Plasma Protein Binding of Lignocaine and Diazepam

P A Routledge, W W Stargel, B B Kitchell, A Barchowsky, D G Shand

Br J Clin Pharmacol. 1981 Mar;11(3):245-50.

PMID: 7213526

Abstract:

1 The percentage of lignocaine free in the plasma of ten females receiving oral contraceptive medication was significantly greater than in 17 males of similar age (18--42 years). 2 In the same subjects the percentage of diazepam free in plasma was significantly greater in the contraceptive treated group than in 11 contraceptive-free females and significantly greater in contraceptive-free females than in males. 3 The differences in lignocaine binding were almost completely attributable to changes in alpha 1-acid glycoprotein concentration, which is reduced by oestrogens. The binding of diazepam was significantly related to albumin, alpha 1-acid glycoprotein and non-esterified fatty acid concentrations which together were related to 55% of the variation in the binding of this basic compound.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
CS310387	Lidocaine Related Compound J			Price

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