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Shatavarins (Containing Shatavarin IV) With Anticancer Activity From the Roots of Asparagus Racemosus

Shatavarins (Containing Shatavarin IV) With Anticancer Activity From the Roots of Asparagus Racemosus

Shankar K Mitra, Neswi S Prakash, Ramachandran Sundaram

Indian J Pharmacol. Nov-Dec 2012;44(6):732-6.

PMID: 23248403

Abstract:

Objectives:
The anticancer activity of shatavarins (containing shatavarin IV) isolated from the roots of Asparagus racemosus (Wild) was evaluated using in vitro and in vivo experimental models.
Material and methods:
The shatavarin IV was isolated from ethyl acetate insoluble fraction (AR-2B) of chloroform:methanol (2:1) (AR-2) extract of A. racemosus roots. The cytotoxicity (in vitro) of shatavarin IV and other shatavarins rich fraction was carried out using of MTT assay using MCF-7 (human breast cancer), HT-29 (human colon adenocarcinoma), and A-498 (human kidney carcinoma) cell lines. The in vivo anticancer activity of shatavarins (containing shatavarin IV) was evaluated against Ehrlich ascites carcinoma (EAC) tumor bearing mice.
Results:
The isolated shatavarin IV (84.69 %) along with shatavarins rich fraction, coded AR-2B containing 5.05% shatavarin IV showed potent cytotoxicity. Oral administration of AR-2B to tumor bearing mice at doses of 250 and 500 mg/kg body weight for 10 days, showed significant reduction in percent increase in body weight, tumor volume, packed cell volume, viable tumor cell count, and increased non-viable cell count when compared to the untreated mice of the EAC control group. The restoration of hematological parameters towards normalcy was also observed.
Conclusion:
The result suggests that the shatavarins (containing shatavarin IV) rich fraction (AR-2B) exhibits significant anticancer activity in both in vitro and in vivo experimental models.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP84633341	Shatavarin IV		84633-34-1	Price

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