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Short-term Dose-Response Characteristics of 2-iminobiotin Immediately Postinsult in the Neonatal Piglet After Hypoxia-Ischemia

Short-term Dose-Response Characteristics of 2-iminobiotin Immediately Postinsult in the Neonatal Piglet After Hypoxia-Ischemia

S Tracey Bjorkman, Zoe Ireland, Xiyong Fan, Willem M van der Wal, Kit C B Roes, Paul B Colditz, Cacha M P C D Peeters-Scholte

Stroke. 2013 Mar;44(3):809-11.

PMID: 23362078

Abstract:

Background and purpose:
To determine the optimal dose of 2-iminobiotin (2-IB) for the treatment of moderate to severe asphyxia in a neonatal piglet model of hypoxia-ischemia.
Methods:
Newborn piglets were subjected to a 30-minute hypoxia-ischemia insult and randomly treated with vehicle or 2-IB (0.1 mg/kg, 0.2 mg/kg, or 1.0 mg/kg). aEEG background and seizure activity were scored after hypoxia-ischemia every 4 h until 24 h and at 48 h and neurobehavioral scores were obtained. Brain tissue was collected and processed for analysis of caspase-3 activity, histology, and tyrosine nitration.
Results:
A dose range of 0.1 to 1.0 mg/kg/dose of 2-IB improved short-term outcome as demonstrated by an increased survival with a normal aEEG and decreased nitrotyrosine staining in the 2-IB-treated animals, indicating decreased cellular damage. Neurobehavior, caspase-3 activity in thalamus, and histology scores were not significantly different.
Conclusions:
Based on survival with a normal aEEG, 0.2 mg/kg 2-IB is likely to be the most appropriate dose for use in future clinical trials in neonates with perinatal hypoxia-ischemia.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP13395352	2-Iminobiotin		13395-35-2	Price

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