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Should Testing Be Initiated Prior to Amoxicillin Challenge in Children?

Should Testing Be Initiated Prior to Amoxicillin Challenge in Children?

Elissa M Abrams, Moshe Ben-Shoshan

Clin Exp Allergy. 2019 Aug;49(8):1060-1066.

PMID: 31141238

Abstract:

Amoxicillin is the most common antibiotic prescribed in children with increasing use over time. While up to 10% of children are labelled as amoxicillin allergic, most children can tolerate amoxicillin after allergy evaluation. It is well documented that the label of amoxicillin allergy in children is associated with adverse health outcomes such as antibiotic-resistant infections. However, it remains controversial how best to assess children for amoxicillin allergy. While in general it is recommended that skin testing be done prior to drug provocation test in the evaluation of amoxicillin allergy, there is increasing evidence that drug provocation testing could be done in lower risk children without skin testing prior. The goal of this article as a narrative review is to review the strengths and limitations of skin testing prior to drug provocation test in children who have a history of either immediate or non-immediate, reactions to amoxicillin.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP61336707-A	Amoxicillin		61336-70-7	Price

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