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Sialic Acid Attenuates the Cytotoxicity of the Lipid Hydroperoxides HpODE and HpETE

Sialic Acid Attenuates the Cytotoxicity of the Lipid Hydroperoxides HpODE and HpETE

Ryosuke Iijima, Takatsugu Ichikawa, Masatoshi Yamazaki

Carbohydr Res. 2009 May 12;344(7):933-5.

PMID: 19329108

Abstract:

Reduction of peroxide molecular species is an essential function in living organisms. In previous studies, we proposed a new function for the sialic acid N-acetylneuraminic acid (Neu5Ac)--that of antioxidant/hydrogen peroxide scavenging agent. On the basis of the reaction scheme, Neu5Ac is thought to act as a general antioxidant of all hydroperoxide-type species (R-OOHs). The concentration of tert-butyl hydroperoxide (t-BuOOH) decreased after co-incubation with N-acetylneuraminic acid. Neu5Ac also decreased the R-OOH concentration in solutions of peroxylinolenic acid (13(S)-hydroperoxy-(9Z,11E)-octadecadienoic acid, HpODE) and peroxyarachidonic acid (15(S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoic acid, HpETE)--two lipid hydroperoxides that participate in many physiological events. Moreover, the cytotoxicity of both these lipid hydroperoxides was attenuated by reaction with Neu5Ac acid. Our results suggest that N-acetylneuraminic acid is a potential antioxidant of most hydroperoxides that accumulate in organisms.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP70981963	15(S)-Hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoic acid		70981-96-3	Price

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