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Side Reactions in the Pyroglutamic acid-7-amino-4-methylcoumarin Synthesis

D Zicane, M Petrova, Z Tetere, G Kreishman, E Brooks, J Karlson, U Kalejs

Int J Pept Protein Res. 1996 Jul;48(1):56-8.

PMID: 8844263

Abstract:

N-Formylpyroglutamic acid-7-amido-4-methylcoumarine and pyroglutamyl-pyroglutamic acid-7-amido-4-methylcoumarin are the major products in the synthesis of pyroglutamic acid-7-amido-4-methylcoumarin by phosphorus pentachloride in dimethylformamide and dicyclohexylcarbodiimide under pyridine activation.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP957311374 Fmoc-L-glutamic acid 1-(7-amido-4-methylcoumarin) Fmoc-L-glutamic acid 1-(7-amido-4-methylcoumarin) 957311-37-4 Price
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