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Silica-based Cerium (III) Chloride Nanoparticles Prevent the Fructose-Induced Glycation of α-crystallin and H₂O₂-induced Oxidative Stress in Human Lens Epithelial Cells

Silica-based Cerium (III) Chloride Nanoparticles Prevent the Fructose-Induced Glycation of α-crystallin and H₂O₂-induced Oxidative Stress in Human Lens Epithelial Cells

Jin Yang, Lei Cai, Sen Zhang, Xiangjia Zhu, Peng Zhou, Yi Lu

Arch Pharm Res. 2014 Mar;37(3):404-11.

PMID: 23828754

Abstract:

This study aimed to investigate whether silica-cerium (III) chloride (CeCl3) nanoparticles could inhibit the formation of advanced glycation end-products (AGEs) and reduce oxidative stress. Silica-CeCl3 nanoparticles were synthesised by adsorption and embedment with micro-silica materials, forming uniform nanoparticles with a diameter of approximately 130 nm. Chaperone activity assays and AGEs formation assays, and intracellular reactive assays were adopted in this study to evaluate CeCl3 nanoparticles effect. UV-visible spectrometry showed that silica-CeCl3 nanoparticles at low concentrations rapidly formed tentatively stable conjugations with α-crystallin, greatly enhancing the chaperone activity of α-crystallin. Moreover, silica-CeCl3 nanoparticles markedly inhibited the fructose-induced glycation of α-crystallin, showing an advantage over the control drugs aminoguanidine and carnosine. Silica-CeCl3 nanoparticles also reduced intracellular reactive oxygen species production and restored glutathione levels in H2O2-treated human lens epithelial cells. These findings suggest that silica-CeCl3 may be used as a novel agent for the prevention of cataractogenesis.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP7790865	Cerium(III) chloride		7790-86-5	Price

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