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Silicon Reagent With Functionalized Tetrafluoroethylene Fragments: Preparation and Coupling With Aldehydes

Oleg V Fedorov, Marina I Struchkova, Alexander D Dilman

J Org Chem. 2016 Oct 7;81(19):9455-9460.

PMID: 27627651

Abstract:

A new fluorinated silicon reagent bearing a functionalized tetrafluoroethylene fragment was prepared from two CF2 building blocks: ethyl bromodifluoroacetate and (bromodifluoromethyl)trimethylsilane. The key C-C bond-forming step involves a difluorocarbene addition/cyclopropane rearrangement sequence. The silicon reagent was coupled with aldehydes and reactive azomethines in the presence of potassium fluoride.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP115262016 (Bromodifluoromethyl)trimethylsilane (Bromodifluoromethyl)trimethylsilane 115262-01-6 Price
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