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Silver Sucrose Octasulfate Nasal Applications and Wound Healing After Endoscopic Sinus Surgery: A Prospective, Randomized, Double-Blind, Placebo-Controlled Study

Silver Sucrose Octasulfate Nasal Applications and Wound Healing After Endoscopic Sinus Surgery: A Prospective, Randomized, Double-Blind, Placebo-Controlled Study

Giancarlo Ottaviano, Stella Blandamura, Elena Fasanaro, Niccolo' Favaretto, Lovato Andrea, Luciano Giacomelli, Andrea Bartolini, Claudia Staffieri, Rosario Marchese-Ragona, Gino Marioni, Alberto Staffieri

Am J Otolaryngol. Sep-Oct 2015;36(5):625-31.

PMID: 25796419

Abstract:

Objectives:
The aim of the present prospective, randomized, double-blind, and placebo-controlled investigation (approved by the Ethical Committee of Padova University Hospital [Italy]) was to assess the effect of a nasal gel containing a combination of silver sucrose octasulfate and potassium sucrose octasulfate (Silsos gel® [SG]) in wound healing after endoscopic sinus surgery (ESS) for chronic rhinosinusitis in terms of: nasal symptoms (SNOT22), endoscopic appearance of the sinonasal mucosa (Lund-Kennedy score), nasal air flow (anterior active rhinomanometry), evidence of mucosal inflammatory processes (nasal cytology and histology), and microbiological growth.
Methods:
Thirty-four patients with chronic rhinosinusitis were randomized on a 1:1 ratio to receive after ESS either SG or placebo (contained only the excipients [carbopol and propylene glycol] in the same concentrations as in SG).
Results/conclusions:
Judging from the present prospective investigation on patients who underwent ESS for chronic rhinosinusitis, treatment with SG seems to enable a significantly faster improvement in specific symptoms (assessed on the validated SNOT22 scale) than placebo. Patients treated with SG also had a quicker improvement in the endoscopic appearance of their nasal mucosa after ESS than patients treated with placebo. These endoscopic improvements in the SG group were also confirmed at the long-term follow-up, while the same did not apply to the placebo-treated group.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP76578819	Potassium sucrose octasulfate		76578-81-9	Price

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