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Simplified YM-26734 Inhibitors of Secreted Phospholipase A2 Group IIA

Rob C Oslund, Nathan Cermak, Christophe L M J Verlinde, Michael H Gelb

Bioorg Med Chem Lett. 2008 Oct 15;18(20):5415-9.

PMID: 18818074

Abstract:

Simplified analogs of YM-26734, a known inhibitor of secreted phospholipase A(2) (sPLA(2)) group IIA, were synthesized and found to also display potent inhibition at low nanomolar concentrations. Analogs were based on the didodecanoylphloroglucinol portion of YM-26734 which contains the predicted active site calcium binding group.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP144337188 YM-26734 YM-26734 144337-18-8 Price
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