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Simultaneous Determination of Eleven Ingredients in Ophthalmic Solutions by Cyclodextrin-Modified Micellar Electrokinetic Chromatography With Tetrabutylammonium Salt

Simultaneous Determination of Eleven Ingredients in Ophthalmic Solutions by Cyclodextrin-Modified Micellar Electrokinetic Chromatography With Tetrabutylammonium Salt

H Okamoto, A Uetake, R Tamaya, T Nakajima, K Sagara, Y Ito

J Chromatogr A. 2000 Aug 4;888(1-2):299-308.

PMID: 10949496

Abstract:

Cyclodextrin-modified micellar electrokinetic chromatography was applied to determine simultaneously 11 active ingredients in ophthalmic solutions. All the ingredients were successfully separated by using the mixed carrier system containing sodium dodecyl sulfate with beta-cyclodextrin and tetrabutylammonium phosphate. The effects of the cyclodextrin type on selectivity were also examined. Excellent separation of the all ingredients was obtained by the use of dimethyl-beta-cyclodextrin. The established method was validated and confirmed to be applicable to the determination of the active ingredients in a commercial ophthalmic solution. These results suggest that capillary electrophoresis can be applied to the quantitative analysis as well as qualitative analysis in pharmaceuticals.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP199684612	β-Cyclodextrin phosphate sodium salt		199684-61-2	Price

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