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Simultaneous Determination of P-Aminobenzoic Acid, Acetyl-P-Aminobenzoic Acid and P-Aminohippuric Acid in Serum and Urine by Capillary Gas Chromatography With Use of a Nitrogen-Phosphorus Detector

Simultaneous Determination of P-Aminobenzoic Acid, Acetyl-P-Aminobenzoic Acid and P-Aminohippuric Acid in Serum and Urine by Capillary Gas Chromatography With Use of a Nitrogen-Phosphorus Detector

J C Libeer, S L Scharpé, R M Verkerk, A J Deprettere, P J Schepens

Clin Chim Acta. 1981 Sep 10;115(2):119-23.

PMID: 6974621

Abstract:

In various studies during recent years, the use of p-aminobenzoic acid has been described in screening tests for exocrine pancreatic function. A synthetic three-unit compound N-benzoyl-L-tyrosyl-p-aminobenzoic acid has been administered orally and hydrolysed in the small intestine in the presence of chymotrypsin to N-benzoyl-L-tyrosine and p-aminobenzoic acid. This study describes a convenient procedure in which, after a selective extraction and derivatization with diazomethane, capillary gas chromatography is used combined with nitrogen-sensitive detection. With the proposed procedure, p-aminobenzoic acid and its major metabolites, acetyl-p-aminobenzoic acid and p-aminohippuric acid, can be monitored in serum and in urine samples.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP150130-B	Aminobenzoic acid		150-13-0	Price

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