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Simultaneous Determination of Propacetamol and Paracetamol by Derivative Spectrophotometry

V Rodenas, M S García, C Sánchez-Pedreño, M I Albero

Talanta. 2000 Jun 30;52(3):517-23.

PMID: 18968011

Abstract:

A first-derivative spectrophotometric method for the simultaneous determination of propacetamol hydrochloride (PRO) and paracetamol (PA) is described. Measurements are made at the zero-crossing wavelengths at 242.0 for PRO and 239.0 nm for PA. The calibration graphs were linear up to 20.0 and 15.0 mg l(-1) of PRO and PA, respectively, the limits of quantification were 0.75 and 0.46 mg l(-1). The possible interfering effects of other substances were studied. The method was applied to determining the stability of PRO in ethanolic solutions and in glucose and saline parenteral solutions.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP66532863 Propacetamol hydrochloride Propacetamol hydrochloride 66532-86-3 Price
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