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Simultaneous Determination of the Counter Ion and Possible Impurity From the Synthetic Route in the Pharmaceutical Substance Prasugrel Hydrochloride

Simultaneous Determination of the Counter Ion and Possible Impurity From the Synthetic Route in the Pharmaceutical Substance Prasugrel Hydrochloride

Wioleta Maruszak, Marcin Cybulski

J Pharm Biomed Anal. 2015 Feb;105:32-8.

PMID: 25527979

Abstract:

A fast and selective capillary electrophoresis method was developed and validated for the simultaneous determination of the hydrochloride and acetic acid content in prasugrel hydrochloride. Because of the poor chromophore, the indirect detection was chosen. Among different compositions studied as the background electrolyte, the pyromellitic acid with diethylamine (DEA) and myristyltrimethylammonium bromide (TTAB) was chosen. During the validation the specificity, linearity, accuracy, precision, range, and stability of the sample solution were confirmed. The results indicate that the method is suitable for the determination of the counter ion and impurity from the synthetic route of the pharmaceutical drug substance in the same assay.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1119977	Myristyltrimethylammonium bromide		1119-97-7	Price

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