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Simultaneous Determination of Tranylcypromine Sulfate and Trifluoperazine Dihydrochloride in Tablets by First- And Fourth- Derivative Ultraviolet Spectrophotometry

Simultaneous Determination of Tranylcypromine Sulfate and Trifluoperazine Dihydrochloride in Tablets by First- And Fourth- Derivative Ultraviolet Spectrophotometry

M Knochen, C Altesor, I Dol

Analyst. 1989 Oct;114(10):1303-5.

PMID: 2619074

Abstract:

A rapid and simple method for the simultaneous determination of trifluoperazine dihydrochloride and tranylcypromine sulphate by first- and fourth-derivative UV spectrophotometry is presented. The procedure consists of extraction in 0.2 m hydrochloric acid, filtration and measurement of the amplitudes of the first- and fourth-derivative spectra at 260 and 274 nm, respectively. A zero-crossing technique is used for the determination of trifluoperazine. Good linearity, accuracy, precision and selectivity were found, and the method is proposed for routine quality control purposes, even for the uniformity of contents test.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP440175-A	Trifluoperazine dihydrochloride		440-17-5	Price

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